PCCA Base Technologies

Atrevis Hydrogel is an advanced topical base that uses a unique hydrogel polymer network along with natural enhancers to drive testosterone far beyond the reach of other bases.

Ideal In Formulations For:

• Testosterone replacement in men
• Hair loss

Common Drug Type:

• Minoxidil
• Testosterone

Ellage Anhydrous Vaginal is the first anhydrous base developed specifically for vaginal applications. It is designed to be gentle on vaginal tissue, release drugs and maintain contact with the mucosa, all while providing a uniquely pleasant experience for patients with various health challenges who need personalised vaginal medication.

Ideal In Formulations For:

• Hormone Replacement Therapy (HRT)
• Pain Management

Benefits:

• No irritation incredibly gentle on mucosal tissue
• In vitro testing shows that Ellage has significant potential to minimize leakage of medication

Dosage Form:

• Vaginal

Formulated Without:

• Preservatives
• Milk
• Egg
• Soy
• Gluten
• Nuts
• Fish

Common Drug Type:

• Estriol
• Estradiol
• Testosterone
• Gabapentin
• Amitriptyline HCl
• Baclofen
• Naltrexone

Lipoderm’s patented core technology means it is the ideal base for deep-penetrating topical formulations for local and systemic absorption of active pharmaceutical ingredients (APIs). It is scientifically proven to deliver APIs through the skin and is supported by an ever-growing portfolio of peer-reviewed journal publications.

Ideal In Formulations For:

• Sports medicine
• Surgery
• Hospice
• Palliative care
• Oncology
• Men’s health
• Podiatry
• Paediatrics
• Veterinary medicine

Benefits:

• Up to 4 drugs can be combined in one formulation
• Developed to enhance penetration of drugs through the epidermis and dermis
• Can be used in place of PLO gels
• Quick absorption, smooth texture, non-sticky

Dosage Form:

• Permeation enhancing base

Formulated Without:

• Almond
• Egg
• Fish
• Gluten
• Hazelnut
• Macadamia
• Milk
• Peanut
• Pecan
• Walnut

Common Drug Type:

• NSAIDs
• Muscle relaxants
• Neuropathic APIs
• Anesthetics
• Anti-nausea APIs
• Sedatives
• Veterinary APIs
• Male hormones and hormone modulators

Lipoderm ActiveMax pairs the patented Lipoderm core technology with the capability to hold active ingredients in salt form at high concentrations, achieving enhanced skin permeation with higher drug capacity.

Ideal In Formulations For:

• Sports medicine
• Surgery
• Hospice
• Palliative care
• Oncology
• Men’s health
• Podiatry
• Paediatrics
• Veterinary medicine

Benefits:

• Developed to hold drugs in salt form at high concentrations
• Up to 4 drugs can be combined in one formulation

Dosage Form:

• Transdermal cream

Formulated Without:

• Almond
• Egg
• Fish
• Gluten
• Hazelnut
• Macadamia
• Milk
• Peanut
• Pecan
• Walnut

Common Drug Type:

• NSAIDs
• Muscle relaxants
• Neuropathic APIs
• Anesthetics
• Anti-nausea APIs
• Sedatives
• Male hormones and hormone modulators
• Veterinary APIs

LoxOral is an all-in-one excipient base that can be used in oral capsule formulations with many types of active pharmaceutical ingredients (APIs), including hygroscopic, static prone and poorly soluble drugs. LoxOral is much more than a filler – it’s an anhydrous innovative capsule excipient base that delivers powerful benefits for your patients.

Ideal In Formulations For:

• All oral-capsule formulations
• Oral hormone replacement therapy (HRT)
• General systemic medication
• Veterinary medicine

Benefits:

• Even distribution: Well-defined, uniform particle size creates improved distribution
• Improved dissolution: Enhances the release of many types of APIs – including poorly soluble drugs – potentially leading to improved absorption.
• Optimal stability: Low hygroscopicity resists moisture and promotes stability, even for moisture-sensitive APIs.
• Reduce static and clumping, improves flowability.

Dosage Form:

• Oral

Common Drug Type:

• Progesterone
• Estriol
• Estradiol
• Testosterone
• Exemestane
• Naltrexone

Mucolox is a revolutionary base that combines the benefits of water-solubility with unprecedented staying power. It can be used with active pharmaceutical ingredients to help deliver long-lasting adhesion for oral and other mucosal surfaces, including oral, rectal, vaginal and oesophageal/gut preparations as well as wound care.

Ideal In Formulations For:

• Dental (mucosistis)
• ENT
• Vaginal conditions
• Rectal conditions

Benefits:

• Polymer network with excellent muco-adhesive properties increasing the contact time of drugs to the mucosal surface
• Does not wash out with water or secretions
• Neutral taste
• Can be diluted with water

Dosage Form:

• Oral, vaginal or rectal gel
• Oral mouthwash or spray
• Oesophageal/gut suspension

Common Drug Type:

• Hormones
• Anaesthetics
• Corticosteroids

Common API’s:

• Nystatin
• Budesonide
• Dexamethasone
• Tranexamic acid

NataTroche tastes great, has a pleasant texture, melts quickly, is made with natural ingredients and its lipid composition improves contact time with oral mucosa.  It is excellent at masking bitter ingredients such as progesterone, which help improve patient compliance.

Ideal In Formulations For:

• Sub-lingual HRT
• Pain Management
• Men’s health
• Paediatrics
• Dental/ENT (thrush/mucositis)

Benefits:

• Fast dissolving lozenge base
• Improves contact time with oral mucosa, potentially improving absorption
• Smooth, creamy base with a pleasant taste
• Masks bitter flavours

Dosage Form:

• Lozenge/Troche

Formulated Without:

• Polyethylene glycol (PEG)
• Gelatin
• Soy
• Gluten
• Peanut
• Fructose
• Glucose
• Maltose
• Sucrose
• Lactose
• Milk
• Egg
• Walnut
• Pecan
• Almond
• Hazelnut
• Macadamia
• Sesame
• Fish(including crustacean)

Common APIs:

• Progesterone
• Testosterone
• Ketamine
• Tadalafil

PermE8 Anhydrous Gel is a permeation-enhancing topical base, using next-generation technology in a silky, smooth anhydrous system to achieve exceptional drug delivery through the skin.

Ideal In Formulations For:

• Paediatrics
• Palliative care
• Hospice and oncology
• Sports medicine
• Surgery
• Podiatry
• Veterinary medicine

Benefits:

• Up to 4 drugs can be combined in one formulation
• Anhydrous
• Silky, smooth texture providing better application

Dosage Form:

• Permeation Enhancing Gel

Formulated Without:

• Preservatives
• Petrolatum/mineral oil
• Soy
• Gluten

Common Drug Type:

• Analgesics and anaesthetics

Common API’s:

• Ketoprofen
• Gabapentin
• Amitriptyline HCl
• Lidocaine

PCCA’s Poloxamer Gels are able to perform as a carrier of water-soluble drugs for percutaneous absorption. When chilled, the gel has a pharmaceutically elegant liquid consistency, is odourless, colourless and non-greasy. It is an emulsifier with soap-like characteristics. Poloxamer gels can be combined with the Lecithin Isopropyl Palmitate Solution to form PLO gels.

Ideal In Formulations For:

• Veterinary medicine
• Wounds and burns
• Ear and sinus cavities

Benefits:

• A bio-adhesive, thermoreversible gel
• At cold temperatures it is liquid, at body temperature it becomes a gel

Dosage Form:

• Topical gel

Common Drug Type:

• Anaesthetics
• Antifungals
• Antibiotics

PracaSil-Plus features a proprietary blend of ingredients, including silicones (in a semipermeable polymer network) and pracaxi oil (which is rich in skin-friendly fatty acids and lipids), it has been helping make a huge difference for patients who want to improve the appearance of scars, including keloid and acne scars.

Ideal In Formulations For:

• All scars, including new, old, keloid, hypertrophic and surgical
• Burns and diabetic wounds
• Stretch marks

Benefits:

• Anhydrous topical silicone base created to improve the appearance of scars
• Can be used alone or combined with various drugs to treat scar tissue
• Contains pracaxi oil rich in skin-friendly fatty acids and lipids

Dosage Form:

• Topical gel

Common Drug Type:

• Corticosteroids and antioxidants
• Anaesthetics and NSAID’s
• Antibiotics and antifungals

SuspendIt is our all-in-one suspending base that has a patented polymer complex. The unique thixotropic flow means it thins as it’s shaken and thickens upon standing, allowing for rapid redispersion of Active pharmaceutical ingredients (APIs) and minimizing sedimentation.

Ideal In Formulations For:

• Paediatric
• Pain Management
• Hospice and oncology
• Veterinary medicine

Benefits:

• Thins when shaken and thickens when standing allowing for rapid redispersion of drugs
• Sugar free with unique natural sweetener
• Pleasant neutral taste
• Ideal for formulations without sugar, casein or gluten

Dosage Form:

• Oral suspension

Formulated Without:

• Gluten
• Casein
• Dairy
• Soy
• Egg
• Nuts
• Alcohol
• Parabens
• Propylene glycol
• Modified food starch
• Carbomer

Common Drug Type:

• Proton pump inhibitors
• Corticosteroids
• Anticonvulsants

VersaBase Cream is an elegant, durable topical cream and an ideal base for topical and vaginal hormone replacement therapy (HRT). It simulates the natural moisturising barrier of the skin through its emulsion system and rubs in quickly, leaving a soft and silky feel.

Ideal In Formulations For:

• Hormone replacement
• Antifungals
• Corticosteroids

Benefits:

• Non-ionic emulsion system that stimulates the natural moisturising barrier of the skin
• Hypoallergenic, odour free and oil free

Dosage Form:

• Topical cream
• Vaginal cream

Common Drug Type:

• Hormones
• Noncomedogenic

VersaBase Gel is transparent, smooth and light to the touch, with a silky feel that spreads and absorbs easily. It is extremely stable and can be used topically, vaginally and rectally. This base can be used in combination with MucoLox™ for patients with vaginal and rectal conditions that would benefit from enhanced mucosal adherence.

Ideal In Formulations For:

• Female / Male Hormone replacement

Benefits:

• Alcohol free
• Quick absorption, smooth texture, no greasy residue

Dosage Form:

• Topical, Vaginal or Rectal gel

Common Drug Type:

• Hormones

WO6 Anhydrous Topical Gel is an elegant, stable base that is suitable for a broad range of dermatological and cosmetic applications. W06 has water activity below 0.6 (Aw < 0.6), classifying it as an anhydrous base, it allows it to accommodate ingredients that are unstable in aqueous environments, such as hydroquinone and ascorbic acid. It is also not tacky or oily, leaving a light, silky feel on the skin that patients will appreciate.

Ideal In Formulations For:

• Dermatology
• Cosmeceuticals
• Veterinary medicine

Benefits:

• Anhydrous topical base for a broad range of applications
• Easy application – no greasy or tacky residue
• Emollient properties which moisturise and softens the skin in use

Dosage Form:

• Topical gel

ZoSil is the industry’s first topical gel base developed specifically for use in veterinary. This exclusive silicone hydrogel base is designed to topically deliver active pharmaceutical ingredients to animal skin. Specifically, it is ideal as a base in formulations for dermatitis and wound care.

Ideal In Formulations For:

• Atopic dermatitis
• General veterinary topicals

Benefits:

• Silicone hydrogel developed specifically for animal skin
• Can be used on mammals, birds and reptiles
• Includes conditioners to promote healthy, shiny fur without matting or gumming

Dosage Form:

• Topical gel

Formulated Without:

• Gluten
• Casein
• Dyes
• Soy
• Dairy

Common Drug Types:

• Antibiotics
• Antifungals
• Anti-inflammatories
• Anesthetics
• Antiseptics
• Mast-cell stabilisers

Common API’s:

• Diphenhydramine
• Hydrocortisone
• Itraconazole
• Ciprofloxacin
• Hydrocortisone
• Ivermectin